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Plasma or cerebrospinal fluid concentrations of vitamin?A and ��-carotene have been reported to be lower in AD patients, and these vitamins have been clinically shown to slow the progression of dementia. Vitamin?A (retinol, retinal and retinoic acid) and ��-carotene have been shown in in?vitro studies to inhibit the formation, extension and destabilizing effects of ��-amyloid fibrils. Recently, the inhibition of the oligomerization of A�� has been suggested as a possible therapeutic target for the treatment of AD. We have recently shown the inhibitory effects of vitamin A and ��-carotene on the oligomerization of A��40 and A��42 in?vitro. In previous in?vivo studies, intraperitoneal injections of vitamin?A decreased brain A�� deposition and tau phosphorylation in transgenic mouse models of AD, attenuated neuronal degeneration, and improved spatial learning and memory. Thus, vitamin?A and ��-carotene could be http://www.selleckchem.com/products/r428.html key molecules for the prevention and therapy of AD. Geriatr Gerontol Int 2012; 12: 180�C188. ""The purpose of the present study was to investigate if performance in a 30-s verbal semantic fluency task (i.e. animal naming) across five elderly aged groups (60�C64; 65�C69; 70�C74; 75�C79; 80�C84?years) would be reflective of aging effect. We analyzed differences in performance across 5-s phases and the moment of first word production in these five http://www.selleckchem.com/products/PF-2341066.html age groups. The following results were obtained: (i) with increasing age, the total number of words produced gradually declined (P? http://www.selleck.cn/products/3-methyladenine.html Depression Scale (GDS) was used to measure depressive state. Age, sex, history of chronic disease, living alone, fall experience, cognitive impairment, instrumental activities of daily living (IADL), the Motor Fitness Scale (MFS), frequency of going out and social support at baseline were used as the main covariates. The Cox regression analysis was used to examine the difference in functional disability stratified according to depressive state. Results:? The incidence of functional disability was 38 persons in the non-depression group and 42 persons in the depression group (RR 2.34; 95% CI 1.46�C3.79).