Scientists in Pfizer's Sandwich, U.K., laboratory developed the pill's active ingredient, Fildena ci

He wonders if, in a world without Fildena and other erectile dysfunction medications, he would spend more time prioritizing his own mental health care. Sharlip says Fildena has promoted a liberalization in attitudes toward sexuality, and that patients are likely to be more forthcoming regarding ED or other problems now that they know there is a pill that they can take. Fildena helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted. One randomized, double-blind, flexible-dose, placebo-controlled study included only patients with erectile dysfunction attributed to complications of diabetes mellitus (n=268).

The frequency of patients reporting improvement of erections in response to a global question in four of the randomized, double-blind, parallel, placebo-controlled fixed dose studies (1797 patients) of 12 to 24 weeks duration is shown in Figure 7. These patients had erectile dysfunction at baseline that was characterized by median categorical scores of 2 (a few times) on principal IIEF questions. In clinical studies, Fildena was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. In another study in healthy male volunteers, co-administration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Fildena (100 mg single dose) resulted in a 300% (4-fold) increase in Fildena Cmax and a 1000% (11-fold) increase in Fildena plasma AUC.

In addition, in a study performed in healthy male volunteers, co-administration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Fildena (100 mg single dose) resulted in a 140% increase in Fildena Cmax and a 210% increase in Fildena AUC. An evaluation of visual function at doses up to twice the maximum recommended dose revealed no effects of Fildena on visual acuity , intraocular pressure , or pupillometry. Even though this total dosage produced plasma Fildena concentrations which were approximately 2 to 5 times higher than the mean maximum plasma concentrations following a single oral dose of 100 mg in healthy male volunteers, the hemodynamic response to exercise was preserved in these patients.

Studies have produced relevant data on the effects of Fildena on cardiac output In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. Blood pressure was measured after administration of Fildena at the same times as those specified for the first doxazosin study.
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