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Topical anti-glaucoma medication was begun if IOP was too high and goniopuncture had not been effective. Patient data were collected and analysed retrospectively. The number of hypotensive glaucoma medications used was recorded, and two drugs in a combination were considered as two drugs. Follow-up data of some patients were collected from local ophthalmologists. http://www.selleckchem.com/products/SB-431542.html The patient consent form was obtained from all participants. The surgical outcome was considered a complete success if the desired IOP level could be achieved without medication. Outcome was considered a qualified success if glaucoma medication was needed to achieve the desired IOP level. We report success rates at three desired IOP levels: a 20%, 25% or 30% IOP reduction. Statistical analysis of results was performed using spss 16.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Summary statistics are presented as medians with range. The Wilcoxon signed ranks test served to test comparisons, and the Chi-square test to test proportions. Statistical significance was set at p?=?0.05. Median follow-up time was 13?months (range 12�C18). Compared to preoperative values, median IOP at all control visits was significantly reduced (Table?2). The median IOP 13?months postoperatively was 10.5?mmHg (4�C15), the median IOP reduction 5.6?mmHg (1.5�C14.5) and the median IOP reduction 37% (12�C78). The change from preoperative to postoperative IOP is shown in Fig.?1. In one eye with elevated http://www.selleckchem.com/products/INCB18424.html IOP (no. 17, Table?2), a valve implant (Ahmed? New World Medical Inc., Rancho Cucamonga, CA, USA) was inserted 5?months after deep sclerectomy. After implantation, the IOP was under control. This eye was excluded from the 1-year analyses of IOP results but was included in the success rate analysis as a failure. The number of glaucoma medications was significantly reduced from 3 (0�C4) preoperatively to 0 (0�C3) at the 13-month follow-up visit (p? http://www.selleck.cn/products/VX-770.html follow-up, a complete success at the 20%, 25% and 30% IOP reduction levels was achieved in 67%, 62% and 52% of eyes, respectively. A qualified success was achieved in 71%, 67% and 52% of eyes. The broken line in Fig.?1 represents the 20% IOP reduction. By the last follow-up visit, YAG-laser goniopuncture had been performed on 10 eyes (48%) at 1�C16?months postoperatively. Median IOP in eyes scheduled for goniopuncture decreased from 16?mmHg (12�C19) before goniopuncture to 12?mmHg (6�C19) measured at the next control visit ��?1?week after goniopuncture (p?=?0.017). Two months after deep sclerectomy, one eye (no. 8) required needling because of an encapsulated bleb.