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It is therefore very unlikely that there would have been any indentation effect on the cornea because of the UBM probe. It is true that it may be difficult to find the exact centre of the posterior corneal surface with only one UBM scan, especially one which is tilted or decentred. We, therefore, take multiple scans and choose the best scan for measurement. The best scan was the one where the IOL optic and pupil were oriented centrally, with the pupil https://www.selleckchem.com/products/INCB18424.html at its largest size and with symmetry of ocular structures. By doing this, we minimized any potential errors and inaccuracies and were thus able to take the highest point of the corneal curvature to represent the centre of the posterior corneal surface. We agree that the cord length lines do not represent the axis of the IOL optic. However, we contend that calculating the angle subtended by the cord length line and line of reference at the point of reference remains valid as one method of measuring of IOL tilt. This may be useful in cases where there is a local deformity or defect (of any aetiology) in the IOL optic. Additionally, the authors also describe an alternative way of measuring IOL tilt. This method has its merits and also its potential drawbacks, one of which is the difficulty in identifying https://www.selleckchem.com/products/PLX-4032.html the scleral spur in some patients. Another is the requirement to first print or export the scan image to a separate computer before the IOL optic tilt can be measured. We are unable to comment upon the reliability or reproducibility of this technique compared with ours. We thank the authors again for this interesting discussion, and we look forward to reading more about developments in this field in the future. ""Purpose We decided to investigate the effects of an acute induced IOP elevation on the prelaminar tissue and on the lamina cribrosa in glaucomatous eyes and in healthy eyes by means of an high resolution Spectral Domain (SD) OCT. Methods We enrolled 10 patients (mean age 70.2 years) affected by primary open angle glaucoma (POAG) and 10 healthy subjects (mean age 70.8 years) as controls. All the subjects were scanned with a SD-OCT with real-time eye tracking at baseline and in the same exact position during IOP elevation performed with an ophthalmodynamometer. The IOP was measured with a Tono-Pen at baseline and during IOP elevation. https://www.selleck.cn/products/U0126.html The SD-OCT images acquired were processed with a computer graphical suite to determine the prelaminar tissue displacement (PTD) and the laminar displacement in the two groups. An analysis of variance was used for evaluating group differences considering statistically significant a P