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The Waiting for a New Heart Study is a 2-year prospective multi-site observational study of patients newly registered for HTx with Eurotransplant. This report focuses on baseline data and presents cross-sectional analyses. The study procedure has been described in detail elsewhere [13]. Briefly, patients newly registered with Eurotransplant were enrolled consecutively in 17 German-speaking HTx centres (one in Austria) between April 2005 and December 2006.Questionnaires measuring demographic, behavioural, and psychosocial characteristics [13] were mailed to patients who had furnished informed consent. Medical information was provided by Eurotransplant. Approval for the study by local ethics committees http://www.selleck.cn/products/BKM-120.html had been obtained before starting recruitment and the study conforms to the principles outlined in the Declaration of Helsinki. Newly registered HTx candidates were eligible for inclusion in the study if they were aged 18?years or older, fluent in German, had not received a donor heart before, and did not need a combined heart�Clung transplantation. All underlying causes of heart failure were accepted. There were 479 patients who met these general eligibility criteria. Ninety-nine patients were not approached, primarily because they were ��in poor condition�� (i.e. not able to answer the questionnaire or interview) as determined by their physician (71%), or had been referred to another hospital [13]. This resulted in http://www.selleckchem.com/products/Y-27632.html 380 patients who were invited to participate. Of these, 340 provided informed written consent. Questionnaires were returned by 318 patients (response rate?=?93.5%).?The 161 nonparticipants (99 not included, 40 decliners, 22 drop-outs) were more likely to be categorized into New York Heart Association (NYHA) class IV (51%) than the 318 participants [24%, ��2(2)?=?32.6, P? http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html range 15.25, M?=?19.7, SD?=?20.1). Medical variables at the time of wait-listing are presented in Table?1. The German Transplant Society Score (GTSS) was calculated to provide an estimate of disease severity [14]. The GTSS was developed from medical characteristics of all patients newly registered in Germany in 1997, and was validated on all new patients registered in 1998, using death-while-waiting as outcome [14]. The model includes left ventricular function [cardiac index, left ventricular ejection fraction (LVEF)], patient location (home, ward, intensive care unit), use of catecholamines, mechanical circulatory support, and dialysis. A higher score indicates a worse health status [14]. Missing data for medical parameters including comorbidities, current stay, and medications ranged from 0.9% (blood pressure, resting heart rate) to 11.