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CCL/core was the ratio of the sum of the length of all cancerous lesions in mm to the total number of biopsy cores (Fig.?1). The RP specimens were processed as previously reported [25]. In summary, all RP specimens were submitted in their entirety. After fixation, the apical and the bladder neck portions of the prostate were separated from the rest of the gland, and serially sectioned sagittally. The http://www.selleck.cn/products/Verteporfin(Visudyne).html remaining prostate was submitted for whole-mount processing with transverse 3�C5?mm slices cut perpendicular to the rectal surface. Each cancerous lesion was evaluated separately and the volume of each lesion was calculated using the formula 0.4 �� length �� width �� cross-section thickness [16]. IC was defined according to the Epstein criteria; tumour volume of ��0.5?mL, confined to the prostate and RP Gleason score of ��6 [10]. All RP specimens were evaluated according to the 2005 ISUP Consensus Conference [24]. Using univariate and multivariate logistic regression analyses, we identified variables http://www.selleckchem.com/products/ch5424802.html for predicting IC from preoperative variables including patient age, PSA and free PSA levels, clinical T stage, prostate volume, biopsy scheme, number of biopsy cores, biopsy Gleason score, percentage of positive cores, maximum cancer length in a core and CCL/core. Incorporating all significant and independent predictors thereof, we constructed a logistic regression-based predictive model for IC. Predictive accuracy of the model was assessed in terms of an area under the receiver operating characteristic curve (AUC) value. For comparison, AUC values were also obtained by applying previously established Epstein biopsy criteria [10], which included: http://www.selleckchem.com/products/VX-770.html (i) PSA density, (ii) biopsy Gleason score, (iii) the presence of tumour in two or fewer cores and (iv) no more than 50% involvement by tumour in any single core, and the Nakanishi et?al. [16] nomogram which included age, PSA density and tumour length in only one positive core, to the study cohort. All analyses were performed using JMP version 7.0 (SAS Institute, Cary, NC, USA). All calculated P values were two-sided and P