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The cutoff of PCV was determined according to the risk of PVT after islet transplantation of a receiver operating characteristic (ROC) curve, and was selected to achieve the best sensitivity/specificity combination. All statistical calculations were performed using SPSS (SPSS Inc., Chicago, IL, USA). Values for p less than 0.05 were considered statistically significant. Characteristics of recipients were summarized in Table 1. Recipients received a mean of 2.19 islet infusions per patient http://www.selleckchem.com/products/MK-2206.html (one transplant 12, two transplants 80, three transplants 24 and four transplants 6). A mean islet mass of 404 999 islet equivalents (IE) were infused intraportally per transplant (5908 IE/kg) in a mean PCV of 4.1 mL (range: 1.5�C15.0 mL). Mean subject height and weight were 169 cm and 67.5 kg, respectively. Mean calculated SLV of recipients was 1484.4 cm3, ranging from 908.1 to 2020.9 cm3. The PCV correlated positively with change in portal venous pressure with r = 0.463 and p http://www.selleck.cn/products/Erlotinib-Hydrochloride.html on two occasions��no underlying thrombophilia was uncovered). In all cases, the partial PVT resolved within a few weeks and did not propagate. Anticoagulation with intravenous heparin and then coumadin was continued for the duration of 6 months. Since 2005, we have ablated the hepatic catheter parenchymal tract routinely with Avitene paste. This single maneuver has substantially increased the safety of therapeutic heparinization after the procedure (8). After the introduction of therapeutic heparinization and limiting the PCV to less than 5 mL for each islet infusion, we have not experienced any further cases of partial PVT in the subsequent 101 procedures over the most recent 4.5 years (Figure 2). We assessed the potential http://www.selleckchem.com/products/ABT-263.html detrimental impact of a partial portal thrombosis on islet function by the SUITO index, a tool to evaluate function of engrafted islet cells and predicts the possibility of insulin independence (17). We measured C-peptide and fasting blood glucose at 5�C7 days and at 1 month after islet transplantation (Figures 3A and B). As controls, we randomly selected a similar number of age-, gender- and duration of diabetes-matched non-PVT subjects undergoing similar islet transplant procedures at our center. There is no significant difference between controls (no PVT) group and PVT group in the number of transplanted islet cells and the number of transplanted islet cells/kg (data not shown).