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This accounted for 0.3% of the total GMS population over 9 years. Of those co-prescribed ACEIs and ARBs, 84% were also prescribed other major classes of http://www.selleckchem.com/products/MS-275.html anti-hypertensive agents. In addition, 35% were prescribed medications for diabetes, 41% received medication for heart failure and 17% received medication for IHD. Overall, there was a significant increase in the rate of ACEI and ARB co-prescribing over the 112-month period. The rate of prescribing was 0.16 per 1000 GMS eligible population in January 2000 and increased to 5.10 per 1000 GMS eligible population in April 2009 (P https://en.wikipedia.org/wiki/Quinapyramine of ACEIs and ARBs was observed in both males (0.41 in January 2000, 5.90 in April 2009) and females (0.17 in January 2000, 4.49 in April 2009) (Figure?1B). The increasing co-prescribing trend was also observed in the three different age groups (P http://www.selleckchem.com/products/GDC-0449.html (0.77 in January 2009, 12.07 in April 2009) and IHD (0.35 in January 2000, 10.43 in April 2009). Females were significantly less likely to be prescribed dual therapy compared with males in the general GMS population as presented in Table?1. Those aged over 45 years old were significantly more likely to be prescribed dual therapy compared with those aged less than 45 years old. Patients prescribed other major anti-hypertensive agents were nearly nine times more likely and those prescribed diabetes therapies were four times more likely be to be co-prescribed ACEI and ARB therapy compared with those without the diseases in the general GMS population. There was no significant increase in prescribing of combination therapy in patients with IHD after adjustment for age and gender. Overall, there were significant increases in co-prescribing after the CALM (P= 0.001) and VALIANT (P= 0.01) trials, but no significant changes in co-prescribing patterns were observed after the COOPERATE (P= 0.09) and ONTARGET (P= 0.2) trials as shown in Table?2. However a decreasing trend was observed after the ONTARGET trial. In sub-group analyses, significant increases in co-prescribing were observed in both males and females, those with hypertension, diabetes, heart failure and IHD and in age groups 16�C45 years and ��65 years after the CALM trial.