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In contrast, significant differences were noted in the comparison of the high intermediate and high risk groups: 3-year FFS 56% vs. 33% (log-rank P? http://www.selleckchem.com/products/Rapamycin.html of patients had either low intermediate (35%) or high intermediate risk (44%) disease (Table?II). Both low (12%) and high (9%) risk groups were proportionally small (Table?II). Similar to the IPI, the AA-IPI was prognostic of outcome for both FFS and OS (Table?II, Figs?1B and 2B) with no difference detected between the low and low-intermediate risk groups (estimated HR of 1��4 and 1��3 respectively, for FFS and OS, P?>?0��3). Significant differences in outcome were noted for the high intermediate versus the high-risk group: 3-year FFS 47% vs. 31% (log-rank P? http://www.selleckchem.com/products/MG132.html were in this category (Table?II). The R-IPI defines three risk groups with 0, 1�C2 and 3�C5 of the IPI factors designated as very good, good and poor. By definition, in our study of patients 60?years or older, all patients had at least 1 factor. Therefore, there were no patients in the very good category. Within the two remaining groups, 40% of our patients were classified as good risk and 60% as poor risk (Table?II). FFS and OS for these two groups were significantly different (estimated HR of 2��0 and 2��1 respectively, P? http://www.selleck.cn/products/Bleomycin-sulfate.html OS estimates were 86%, 74%, 58% and 36% for the respective E-IPI groupings (Fig?2d). Within the E-IPI risk groups, significant differences in FFS and OS were detected between both the low and low intermediate risk groups and the high intermediate and high risk groups (estimated HR of 2��1 and 1��9 for FFS and OS respectively, P?