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Univariate analysis was used to assess the impact of various donor and recipient characteristics other than diabetes on the survival of allografts from D-SCDs. A Cox proportional hazards model was used for multivariate analysis of factors, which influence D-SCD allograft survival. During our 10-year study period, only 31 recipients http://www.selleckchem.com/products/nutlin-3a.html of diabetic organs were identified as having diabetes before transplantation��partly a result of unknown diabetes status for a large number of recipients during this period. The relative percentage of recipients with ��unknown diabetes status�� started to decrease starting in 2002 as the rate of identification of the diabetes status of recipients before transplantation improved considerably over time. Therefore, we performed a separate analysis to compare outcomes based on the diabetes status of the recipient using data on patients transplanted between 2002 through 2009��a period when the vast majority of transplants of diabetic organs to diabetic recipients was identifiable in the UNOS registry. All data was obtained from the standard transplant and research (STAR) file by the United Network for Organ Sharing (UNOS) dated November 27, 2009. Organ discard data was also obtained from UNOS and was based on OPTN data as of January 7, 2011. We also obtained organ discard data directly from UNOS for the period from 1995 through 2008 as part of separate data requests (request 122810�C9 and 20120108�C3). Statistical analysis was performed with Stata 11.2 (Stata Corp., College Station, TX, USA). Between 1994 and 2008, the number of kidneys recovered http://www.selleckchem.com/products/AC-220.html from deceased diabetic donors increased http://www.selleck.cn/products/Romidepsin-FK228.html from 173 to 1327 annually��almost an eightfold increase (Figure 1). However, this was also accompanied by a 13-fold increase in the discard rate of kidneys from diabetic donors, from 49 to 581 kidneys annually. Due this increase in discard rate, despite the overall increase in number, there was an overall decrease in the utilization of D-SCD kidneys for transplantation during that period, from 71.6% to 56.2% (Figure 1, p