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6, P?=?0.012), but for positive basal margin in robotic radical prostatectomy (odds ratio 4.5, P? http://www.selleckchem.com/products/rxdx-106-cep-40783.html radical prostatectomy. Apical positivity on extended transrectal biopsy represents a predictive factor of positive surgical margin. Small prostate volume is associated with higher risk of positive surgical margins at the apex in open radical prostatectomy and at the base in robotic-assisted laparoscopic radical prostatectomy. PCa is the fastest growing cancer in Korea.[1] Compared with USA men, a significant proportion of PCa shows poor differentiation in Korean men, regardless of the preoperative serum PSA level or clinical stage.[2] PSM after RP are well known independent predictive risk factors of disease progression.[3, 4] However, there were some reports that the effect on biochemical disease-free survival was highly influenced by specific positive-margin location. The corresponding impact of +AM, the most common location, remains controversial, but the posterolateral site, the second most common location, correlates with the highest risk of biochemical recurrence.[5, 6] Predictors of http://www.selleckchem.com/products/CP-673451.html the specific location of PSM are not yet fully understood. https://en.wikipedia.org/wiki/Crotamiton Body mass index was has been identified as an independent predictive factor for +AM, though it is applicable only to patients who have undergone RALP.[7] One study found that whereas positive apical biopsies did not predict for +AM, positive basal biopsies predicted for +BM.[8] However, another study contradicted those results, finding no such relationship between positive biopsy site and PSM.[9] The present study was undertaken to investigate the preoperative predictors of PSM and their locations after RP in a Korean population. Between 2000 and 2010, a total of 3707 consecutive patients with biopsy-confirmed PCa who underwent RP at three tertiary referral centers were invited to participate in the present study. After institutional review board approval, the clinical records of the participating patients were retrospectively reviewed. Nine surgeons using similar techniques provided data on a standardized spreadsheet. A total of 334 patients (9.7%) with seminal vesicle invasion or positive lymph nodes were excluded from the study, as were a further 146 patients (3.9%) who had received radiotherapy and/or neoadjuvant androgen deprivation therapy before surgery. The remaining 3227 patients with clinically localized PCa were included in the present analysis.