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Seven patients received a retransplant after PTLD, with no PTLD recurrence reported. Using all 235 PTLD cases, the covariates associated with better patient survival were more recent year of PTLD diagnosis (adjusted hazard ratio AHR 0.86, p http://www.selleck.cn/products/Romidepsin-FK228.html rate among PTLD cases in the 1990s (3). However, more recent single center series and prospective trial data suggested a better prognosis (4,5). Srivastava et al. reported no deaths in their single center series of 7 PTLD cases (5). McDonald et al., though they found an unacceptably high PTLD rate in their multicenter trial, reported only 1 death in 19 cases (4). Prognosticating the outcome of PTLD has also changed over the years. Prior prognostic factors were similar to traditional Hodgkin lymphoma: http://www.selleckchem.com/products/AC-220.html elevated lactate dehydrogenase, advanced disease stage, multifocal or CNS disease (6�C8). The advent of anti-CD20 antibody treatment and CD20 tumor staining has added to the list, such that CD20 negative tumors carry a worse prognosis (9). However, EBV positivity has been controversial, with some studies suggesting that EBV negative PTLD had a worse prognosis and other studies suggesting no difference in prognosis (8,10). We therefore wished to determine recent outcomes and prognostic factors for PTLD http://www.selleckchem.com/products/nutlin-3a.html cases in recent years in the pediatric kidney transplant population. We undertook this retrospective special questionnaire study of centers that participate in the NAPRTCS database. Details of the data collected by NAPRTCS have been covered in detail previously. Briefly, the transplant database has been active continuously since 1988 and has collected data on more than 11 000 transplants performed in children under 21 years of age across more than 130 centers within the United States, Canada, Mexico and Costa Rica. One of the questions in the transplant follow-up form of the master database asks whether PTLD has occurred. The definition of PTLD, similar to other transplant registries such as OPTN, is by center report. In this form, the centers are not asked about additional PTLD diagnosis or confirmation criteria intervention or outcome details related to the PTLD. The main transplant database of NAPRTCS, at the time of the study, had 235 PTLD cases reported.