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In the week following CPVI, 3 patients experienced early recurrence. During the 12-month follow-up, 27 patients experienced recurrence, 20 of whom required repeat ablation. Groups were comparable in age, gender, AF duration, LA diameter, vagal response, http://www.selleckchem.com/products/a-1331852.html and LA volume, although the proportion of patients with persistent AF was significantly larger in the group experiencing recurrence (48.1% vs 25.0%, P = 0.04). In the group with successful CPVI, the mean RR interval duration was significantly decreased from preprocedure levels at 1 hour and 24 hours (P http://www.selleckchem.com/products/avelestat-azd9668.html an SDNN (standard deviation of the normal-normal RR interval durations) significantly lower than the group with AF recurrence (23.88 �� 13.31 vs 36.56 �� 18.81, P = 0.02). By 24 hours, both groups exhibited a marked change compared with preprocedure levels (Table?2). In the 57 (67.5%) patients free from recurrence, time-domain indices, root mean square successive difference (RMSSD), and pNN50 (proportion of intervals differing from their neighbors by more than 50 milliseconds) were significantly reduced with respect to preprocedure levels at all follow-up intervals with the exception of 12 months (Table?2, Figure?1). There was also a significant difference between patients with successful procedures and patients with recurrence at the 1 hour follow-up interval for the pNN50 index http://www.selleck.cn/products/PLX-4720.html (6.99 �� 11.55 vs 14.32 �� 15.41, P = 0.04). In these data, if a reduction of ��10 in SDNN is exhibited by a patient at the 1 hour follow-up interval with respect to their preprocedure level, there would be a sensitivity of 96%, specificity of 63%, positive predictive value of 89%, and negative predictive value of 83% for freedom from AA recurrence. In the frequency-domain HRV indices, we observed a significant reduction in HF power at all follow-up intervals for patients with successful procedures, consistent with sustained vagal withdrawal (Table?3, Figure 2). In contrast, patients with recurrence showed no change from preprocedure levels. In LF power, we observed a significant reduction up to 6 months in patients with successful procedures, and a significant reduction at the 24 hour and 6 week intervals in patients with recurrence. In the LF/HF measure, we observed a reduction up to 3 months in patients with successful procedures, and a reduction only at 24 hours in patients with recurrence. There was also a significant difference between patients with successful procedures and patients with recurrence at the 1 hour follow-up interval for the LF index (124.60 �� 216.49 vs 212.46 �� 243.54, P = 0.01) and HF index (171.41�� 309.24 vs 356.27 �� 414.18, P = 0.