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2 (SAS Institute, Inc., Cary, NC, USA). The p values are two-sided with p �� 0.05 considered statistically significant. Bisphosphonate use was low at baseline (n?=?3044 users, 2%) but became increasingly common over the course of follow-up (10,349 users at year 3, 7% of those remaining at risk of CRC, of whom 3373 used http://www.selleckchem.com/products/dabrafenib-gsk2118436.html 72% of baseline users reported a physician diagnosis of osteoporosis compared with only 6% of nonusers (Table 1). Baseline users were more likely to be older, white, of lower BMI, nonsmokers, and to have recently undergone a cancer-screening test. Users also had higher total calcium intake, vitamin D intake, and 5-year probability of hip fracture. Women who reported use anytime during the first 3 years of the http://www.selleckchem.com/products/sch772984.html study (including baseline) were generally similar to baseline users but, on average, were slightly younger, had lower calcium, vitamin D, and 5-year probability of hip fracture��trends that likely reflect the prescription of bisphosphonates to a broader patient population. Over the course of the study, use of the aminobisphosphonate alendronate accounted for >90% of the total person-time of bisphosphonate use. Based on a multivariable-adjusted model, the estimated HR of CRC risk comparing bisphosphonate users to nonusers was not different from the null at the ��?=?0.05 level of significance (HR?=?0.88; CI 0.72�C1.07; p?=?0.19; Table 2). This fully adjusted estimate was attenuated from an age-only adjusted estimate. Because alendronate use predominated, type-specific estimates for risedronate and other types (etidronate and tiludronate) were not very precise. The magnitude of the association was stronger for recent adopters of bisphosphonates than for longer-term users. We explored whether the association between CRC risk and bisphosphonate use depended on BMI, family history of CRC, hormone use by type, vitamin D and calcium intake, cancer-screening tests, and indication for bisphosphonate use. The strongest associations were among women with low http://www.selleck.cn/products/ly2157299.html vitamin D intake (