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Melanomas were situated on the truck (36%), lower limb (27%), upper limb (24%), head & neck (13%). Nineteen percent were T2, 45% T3 and 34% T4 lesions. Fifty-eight SNB positive patients had MRI and PET staging scans. No distant melanoma metastases were detected in these scans. There were two incidental PET findings (one colonic polyp and one thyroid nodule). Fifty-one patients had a completion lymphadenectomy of which five had additional positive nodes in the lymph field. Staging scans for stage IIIa melanoma did not detect any distant metastatic disease and did not alter the planned clinical management of the regional field melanoma metastases that were detected by the SNB. 38 Disease-specific mortality in sentinel node-negative http://www.selleck.cn/products/Cisplatin.html melanoma patients E. D. Whitman1,2,3, R. Bustami2,3 1Atlantic Melanoma Center; 2Office of Grants and Research; 3Atlantic Health, Morristown, New Jersey, USA Sentinel node (SN) negative melanoma patients from the Surveillance Epidemiology and End Results (SEER) database were analyzed to identify factors predicting early mortality from melanoma and all other causes. This is an update of a prior study done with an earlier version of the SEER database. The updated SEER database was used to identify all SN negative melanoma (NEG) patients, beginning in 2003 when SEER first recorded SN data. Time between diagnosis http://www.selleckchem.com/products/PD-0325901.html and date of death or last follow-up were recorded, as were patient related demographic data including age, gender, race, primary site (head/neck, trunk or extremities), ulceration status and tumor thickness (T1, T2, T3, T4). Disease-specific and overall mortality were analyzed in multivariate Cox proportional hazards regression models. A http://www.selleckchem.com/products/3-methyladenine.html second analysis divided patients who died into two groups based on median survival to test for factors specifically related to early mortality. There were 13?343 SEER patients in the NEG group. Through end of 2007 (median follow-up 25?months), 802 (6.0%) had died, 360 (2.7%) from melanoma. By Cox models, factors significantly associated (P?