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Accurate histological confirmation and the exclusion of biliary and/or arterial problems are needed for diagnosis. Regardless of the relapse pattern, prospective studies have shown that approximately 25�C30% of patients develop cirrhosis in the graft after 5?years of follow-up (8�C44% at 5�C10?years) [4, 6]. The natural history of cirrhosis is also more aggressive than that observed in non-transplanted patients [5]. The first episode of decompensation, normally in the form of ascites, usually occurs after a median of 8?months from http://www.selleckchem.com/products/dabrafenib-gsk2118436.html diagnosis of cirrhosis in the graft, with a cumulative rate of 42% and 63% in the first and third http://www.selleckchem.com/products/sch772984.html year since compensated cirrhosis respectively. Factors that predict decompensation include a Child-Pugh?>?A class, a serum albumin level http://www.selleck.cn/products/z-vad-fmk.html has not improved in HCV-recipients in recent years [13, 14]. The indications for LT are the same as in cirrhosis or hepatocellular carcinoma due to other causes. However, when assessing this indication, it is important to evaluate in the potential recipient the presence of pretransplant factors associated with poor post-LT prognosis, such as older age [15-17], hepatocellular carcinoma [9, 13, 15, 18-24], diabetes [25] and metabolic syndrome [26].