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The expected number of cases of dementia cases was 5.042 leading to standard mortality rate for dementia (SMR)dementia?=?1/5.042?=?0.20 and a 95% CI from 0.01 to 1.11. For AD, the expected number of cases was http://www.selleck.cn/products/nlg919.html 0.91, resulting in SMR?=?0 with a 95% CI from 0 to 4.06. The present study on 69 patients with NTG who were tracked in nationwide registers for a mean follow-up period of 12.7?years did not find that NTG was associated with increased risk of developing dementia/AD compared with the risk for the general population. The small number of cases led to wide confidence limits. Thus, for dementia, the data are compatible with a 1.1 times increased rate for the glaucoma patients compared with the whole population even though SMRdementia was http://www.selleckchem.com/products/bmn-673.html is estimated that at least two-thirds of patients with dementia in Denmark will be diagnosed in secondary hospital health care (as an inpatient or outpatient) and consequently be recorded in the national health registers (Phung et?al. 2009). Nevertheless, it should be noted that general practitioners or private practicing specialists in psychiatry or neurology might diagnose persons with dementia without this being recorded in the registers. Therefore, it is most likely that only patients with the more severe forms of dementia are recorded in the registers. As the patients with NTG who were included in the study were diagnosed at a Glaucoma Clinic at a University Hospital in http://www.selleckchem.com/products/pexidartinib-plx3397.html Copenhagen (Rigshospitalet), these patients may have a greater chance of being diagnosed with dementia if this disease develops during follow-up as doctors see these patients frequently compared with the general population. Thus, the effect of this kind of bias (Berkson bias) would tend to increase the rate of dementia among the NTG patients compared with the general population and cannot explain our negative findings. We cannot identify any other kind of bias that may explain the results of the study. Theoretically, the low rate of dementia/AD could be interpreted as a result of neuroprotection of some of the anti-glaucoma medications. Betaxolol and dorzolamide have been investigated previously in relation to a neuroprotective effect, but without convincing positive results and brimonidine is now under investigation (Krupin 2007).