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5 years afterward (median 10.4 years; 42% followed until death). Only 51% of the women remained alive after 15 years compared with 67% expected (p? http://www.selleckchem.com/products/Y-27632.html fractures (14%) were caused by severe trauma (eg, motor vehicle accident), whereas 373 (66%) were attributed to no more than moderate trauma (Table 2). Of the latter, 160 fractures were the result of a fall from standing height or less, and 213 (mostly vertebral fractures) occurred ��spontaneously�� in the course of everyday activities. Eighty-seven fractures (15%) resulted from a specific pathologic lesion (almost all in the axial skeleton owing to metastatic http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html malignancy). The etiology of the remaining 27 fractures was uncertain. After 15 years of follow-up, an estimated 57% of these patients had experienced at least one new fracture, which was more than the expected 43% (p? http://www.selleck.cn/products/pexidartinib-plx3397.html were excluded; further exclusion of an additional 137 fractures that were only discovered incidentally, including 120 asymptomatic vertebral fractures (29 found in the course of cancer monitoring and 91 on radiographs taken for some other purpose), reduced the relative risk to a level that was no longer statistically significant (SIR 1.2; 95% CI 0.99 to 1.3). However, the fractures traditionally ascribed to bone loss include only those resulting from moderate trauma. These detailed site-specific data are also shown in Table 3. The risk of any subsequent moderate trauma vertebral fracture, excluding pathologic fractures and those found incidentally, was only elevated 1.9-fold (95% CI 1.4 to 2.5) compared with the nearly 6-fold increase when all thoracic and lumbar spine fractures were included. The only other increased risks were for cervical vertebrae (SIR 5.3; 95% CI 1.