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Although antiviral treatment using NUCs effectively suppresses HBV replication, patients may still be at risk for development of liver-related events (LREs) including hepatic decompensation, hepatocellular carcinoma (HCC), and liver-related death [42]. Thus, attempts have been made to utilize http://www.selleck.cn/products/Everolimus(RAD001).html TE to predict the occurance of LREs, and several studies have reported an association between the LS value and the risk of development of LREs in patients with CHB undergoing antiviral treatment [43, 44]. Kim et?al. [45] investigated the role of TE as a predictor of LRE development in patients with CHB receiving NUCs and with histologically advanced liver fibrosis (��F3) and a high viral load (��2000?IU/ml). During a median follow-up period of 27.8 (range, 12.6�C61.6) months, the LS value was identified as an independent predictor of development of LREs (P?=?0.044; HR, 1.038; 95% CI, 1.002�C1.081). In addition, patients with an LS value >19?kPa were at a significantly greater risk for development of LREs than those with an LS value ��19?kPa (P?=?0.001; HR, 7.176; 95% CI, 2.257�C22.812). Although the incidence of LREs was similiar in patients with F3 and F4 fibrosis http://www.selleckchem.com/products/ch5424802.html stages (22.2% vs. 13.6%; P?=?0.472), the incidence differed significantly between patients with LS values ��19?kPa and those with LS values >19?kPa (6.9% vs. 44.4%; P? http://www.selleckchem.com/products/azd9291.html the long-term prognosis in patients with CHB undergoing antiviral treatment despite histological assessment using LB. A recent study [46] proposed LS cut-off values for subclassification of HBV-related cirrhosis based on the Laennec staging system, which is correlated with clinical stages [47]. With the cut-offs for F4B�CFC (vs. F3�CF4A) and F4C (vs. F3�CF4B) of 11.6?kPa and 18.2?kPa, respectively, the authors demonstrated that the incidence rate of LREs increased according to fibrosis stage F3�C4A vs. F4B�C4C (7.4% vs. 17.1%) and stage F3�C4B vs. F4C (13.8% vs. 18.8%) and that the rate also increased dramatically with LS values according to the corresponding cut-off values of 11.6?kPa (5.9% vs. 23.1%) and 18.2?kPa (9.8% vs. 33.3%) respectively (all P?