Just kind of bummed out. I have been using Tysabri now for over a year, I was originally taking this when it first came out and noticed a big difference within 2 treatments, but because of the FDA pulling it for pml, it set me back big time. I am in a wheelchair full time now and I hate it. I hate not being able to do things with my children. SUX. I am feeling a little down right now, it is nice out and I would just like to walk,. Sorry for the negativity, just having one of those days today.