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The statistical analyses were carried out on Microsoft Excel 2007. The appropriateness of the fluids http://www.selleckchem.com/products/liproxstatin-1.html prescribed was analysed separately from the appropriateness of the fluids administered. Either Pearson's chi-squared test or Fisher's exact test was used to calculate differences between groups. Given the effect of this intervention on six different hypotheses was to be evaluated, a Bonferroni correction was used. With an �� = 0.05 and the number of hypotheses, n = 6, the adjusted value for statistical significance was therefore P https://en.wikipedia.org/wiki/Ketanserin days were recorded across the two sites during the 8 weeks. After the following exclusions (day of operation, preoperative hydration, parenteral nutrition, palliative care, renal failure and resuscitation for blood loss), 253 maintenance i.v. days, 134 gastric loss replacement i.v. days and 108 bowel loss replacement i.v. days were included in the statistical analysis. It must be noted that these figures are not mutually exclusive as some patients received both maintenance and replacement i.v. fluids. There were fewer maintenance i.v. days seen in the hospital 1 post-intervention group (49) than in the pre-intervention group (86). Compared to the 95 bowel http://www.selleckchem.com/products/midostaurin-pkc412.html loss replacement i.v. days seen at hospital 1, only 13 were seen at hospital 2. Results for prescribing and administration of i.v. fluids at the two hospitals are shown in Table?1. At baseline, 22% of hospital 1 maintenance i.v. fluid prescriptions and 45% of those at hospital 2 were appropriate. Inappropriateness was both in type and volume of the fluid prescribed. Replacement of fluid losses at baseline was appropriate in 75% for both gastric and intestinal losses at hospital 1 and 100% and 8% for gastric and intestinal losses, respectively, at hospital 2. The percentages of appropriately and inappropriately administered maintenance i.v. fluids at hospital 1 and hospital 2 were similar to the results of the maintenance i.v. fluid prescriptions as shown in Table?1. Following the intervention, there was a significant decrease in the rate of inappropriately prescribed maintenance i.v. fluids from 74% to 43% (P