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Specifically, patients with a KPS of 80 or worse had a HR of 4��66 (P?=?0��010) for NRM relative to those patients with a KPS of 100. Each additional prior chemotherapy regimen was associated with a HR for NRM of 1��31 (P?=?0��03). Prior monoclonal antibody therapy was associated with a decreased risk of relapse (HR 0��60, P?=?0��005) but not RM, NRM or overall survival. Disease status was also found to be prognostic of outcomes: patients in CR2+/PR2+ at the time of transplant were at increased risk http://www.selleck.cn/products/CP-690550.html of relapse (HR 2��35, P? http://www.selleckchem.com/products/ABT-263.html et?al, 2005; Brown et?al, 2005; Kalaycio et?al, 2006a,b; Armenian et?al, 2008). In a comprehensive study of late mortality in survivors of ASCT, Bhatia et?al (2005) revealed that mortality exceeds those of the general population until 10?years after ASCT in certain subgroups of patients. Despite recognition of http://www.selleckchem.com/products/abt-199.html the long-term sequelae of ASCT for all haematological malignancies, there is limited data specifically regarding DLBCL. The study by Bhatia reported on 392 cases of NHL but did not distinguish between histological subtypes and included many cases of low-grade lymphoma (Bhatia et?al, 2005). Here we report a 15-year follow-up on the largest single-institution experience of 309 consecutive patients with DLBCL who underwent ASCT with a uniform preparative regimen. Consistent with previous observations, the majority of relapses occurred within the first 2?years after ASCT (van Besien et?al, 1995; Bolwell et?al, 2002; Damon et?al, 2008; Fu et?al, 2008b; Vellenga et?al, 2008; Fenske et?al, 2009). There is a substantial reduction in the relapse rate after 5?years, which has been the basis for declaring patients ��cured�� of disease after this time point. However, in examining cumulative mortality rate, it is clear that there is a constant accumulation of patient deaths beginning 2?years after ASCT and continuing indefinitely well beyond the 5-year time point. Relapses are uncommon after 5?years and the proportion of deaths occurring from non-relapse causes overtakes relapse-related deaths approximately 8?years after ASCT.