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For survival analysis, http://www.selleckchem.com/products/dabrafenib-gsk2118436.html animals were censored if they were still alive at the time of data accrual. The TK activity in serum was determined using a 125I-based radioenzyme assay as previously described.9 The reference interval (normal 0�C7 U?L?1) was derived from a previous veterinary study.9 Data were entered into a spreadsheet (Microsoft Excel 2007, Microsoft Ltd, Microsoft UK, Reading, UK) and checked and corrected as required. Statistics were performed using the package Minitab? version 15.1.1 (MINITAB Ltd, Coventry, UK). After performing basic descriptive statistics, univariable comparisons employed the nonparametric Mann�CWhitney and Wilcoxon Signed-Rank tests. TK values were logged for graphical presentation. Basic survival distributions were examined using the Kaplan�CMeier method and comparisons tested with the Log-Rank test. The critical probability was defined as P The most commonly encountered breeds were cross-breed dogs (16/73, 22%), Boxers (6/73, 8%), Golden Retrievers (5/73, 7%) and Dogue de Bordeaux and Labrador retrievers (both 4/73, 5%). The mean and median ages were 6.4 and 6.5 years, respectively (range 1�C14 years). There were 41?male and 32 female dogs. There was 1 dog with stage 1 disease, 2 dogs with stage 2 disease, 13 dogs with stage 3 disease, 34 dogs with stage 4 disease, 16 dogs with stage 5 disease and 7 dogs in which staging was not undertaken because of financial reasons or the owners' wishes. Thirty two dogs were classified as WHO substage ��b�� and the remainder substage ��a��. Most of the dogs were treated with chemotherapy protocols. Sixty three animals received a modified Madison�CWisconsin 25-week discontinuous21 (CHOP-based) protocol (Table 2) initially, and six animals received a COP-based protocol (Table 3). One dog received one dose of l-asparaginase only, one dog prednisolone only and two dogs were not treated as this was declined by the owner(s). Seventy three dogs had TK activity measured initially prior to any treatment. Initial TK activity demonstrated a high degree of variation (median 6.2; range