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Participants�� median age at LT was 6 years and the median period since LT was 15 years. Of the 116 participants, 76% considered their quality of life as good or very good. Seventy-five patients (65%) were attending schools, 27 of whom were 2 years or more below the age-appropriate level. Of the remaining 41 patients, 26 had a job and 15 were unemployed. Poor compliance http://www.selleck.cn/products/BafilomycinA1.html with medications was reported by 52 patients (45%). Alcohol consumption was lower than in the reference population (p http://www.selleckchem.com/products/blz945.html may put them at risk of experiencing developmental problems which, mainly during adolescence, may subsequently affect their personal and social life, educational level and career. Previous pediatric studies have provided substantial evidence that LT improves the quality of life (QOL) and that QOL improves with time after transplantation (6�C12). A review of 11 research studies assessing health-related QOL in children and adolescents after LT suggested the existence of a trend toward poorer QOL in some areas of physical, psychological, social and family functioning, compared with healthy populations (12). Most LT children http://www.selleckchem.com/products/hydroxychloroquine-sulfate.html undergoing LT exhibit emotional and behavioral disturbances (9�C16). With respect to intellectual and neurocognitive evaluations, lower than average results have been reported (9,11,13,17�C20). However, in contradiction with impaired neuropsychological development, it was reported that LT did not greatly affect schooling (7,10,13,17,21). Most of these pediatric studies were conducted among heterogeneous samples with respect to age and the period since LT, and psychological and social development has often been assessed by parental reports (8�C11,21). In a recent study including self-assessment of QOL, 11- to 18 year-old adolescent liver transplant recipients reported physical and psychosocial function very similar to that of a healthy middle school population, despite poorer general health (22).