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All ��last 12 months�� users were asked to report on the typical amounts they used in a session, the maximum amount used in a session and also maximum number of consecutive days of use. Users were asked to select the dose that best described their typical session use from a number of fixed dose amounts. Subsequently, based on the http://www.selleck.cn/products/Verteporfin(Visudyne).html normal distribution of responses, ketamine users were divided into low-use, medium-use and high-use typical dose groups: 31% (373) reported using 0.125?g or less during a typical session (low), 35% reported using 0.25 or 0.5?g (medium), with 34% (404) reporting use of 1?g or more (high) during a typical session. Some users (4.9%; 63) could not remember or did not know how much they took and 5.2% (67) reporting regularly taking ��3?g in a session. In term of maximum amounts ever used, 54.2% (674) reported having ever taken a gram or more in a session, 24.6% (307) reported ��3?g in a session and 6.6% (74) reported ever use of ��5?g in a session. With regards to frequency of use, the mean number of maximum number of consecutive days of use http://www.selleckchem.com/products/VX-770.html was 3.5 (modal 2), with 11.6% (143) reporting ever using on 7 days or more consecutively. Last-month users (792) were asked to report how many days they had used ketamine in the last month with a mean of 4.2 days (sd 4.87) with a modal of 1 day/month. Users were divided into low (1�C4 days/month, 70% of subjects) medium (5�C8 days/month, 15.6% of subjects) and high (��9 days/month, equating to more than twice weekly, 13.4%). Route of use was only assessed for the subgroup of users for whom ketamine was the most recent drug they had taken for the first time (n= 307). Among this group 95% reported intranasal use. All last-year users were also assessed for dependence using the seven Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for dependence [19]. These DSM-IV criteria were operationalized so as to provide a proxy measure for dependence. Given the diversity of the sample, additional markers of problematic use were also sought (personal concern over use, concern over use expressed by family or friends, a persistent desire or strong urge to use, desire to use less and desire for help to cut down). Using this proxy marker for the presence of dependence, 17% (218) of the sample could be considered as being dependent on ketamine (i.e. they reported experiencing three http://www.selleckchem.com/products/ch5424802.html or more DSM symptoms together at some time in the last 12 months). Of last-month users, 22.7% (180) indicated that they would like to use less ketamine, with 5.9% (47) indicating that they would like help with their ketamine use. Dependence was strongly associated with amount (higher typical amounts used per session) (%, ��2= 170.9, P