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In those cases, we reported the ��trimmed mean�� of LI https://en.wikipedia.org/wiki/Crotamiton values because the possible LI values vary greatly [Wilke and Schmithorst, 2006]. The trimmed mean yields a mean for only the middle 50% of all possible LI values. LI was calculated for regions of interest (ROI) described in detail below. Cerebellum LI values were reversed given the expected contralateral activation to more accurately assess for differences in degree of lateralization. Given that language lateralization is often a skewed population because the majority of any population is has left LI values, categorical distribution of language dominance was also used to examine developmental trends and for making comparisons with the distribution found in adults. We categorized regional language dominance as: left hemisphere https://www.selleckchem.com/products/CP-673451.html (LH) dominance defined by LI values >0.2, right hemisphere dominance defined as LI values https://www.selleckchem.com/products/rxdx-106-cep-40783.html the group map��thus impacting LI calculations. We first utilized an inclusive ROI as we are investigating the range of possible activation. ROIs were defined by anatomic designations using the Wake Forrest PickAtlas [Maldjian et al., 2003]. They included: (1) Anatomic Label for Inferior Frontal Gyrus (IFG), (2) Anatomic Label for Middle Frontal Gyrus (MFG), (3) Wernicke's Area (WA, as defined by Brodmann's areas 21, 22, and 39) Anatomic Label for Cerebellum. Descriptive statistics were used to characterize demographic, neuropsychological, task performance (task accuracy, baseline reaction time, experimental task reaction time), and LI variables. To examine the relationships among these variables the appropriate parametric and nonparametric two-tailed correlation analyses (depending on the nature and distribution) were conducted.