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5%. There were no significant differences in the PSM rates between the three surgical modalities (P?=?0.503). There was a trend toward higher PSM rates in the higher-risk group. We were not able to find significant differences in positive rates of surgical margin between each surgeon (Table?2). The +BM rates rose from 2.0% in the low-risk group to 5.8% in high-risk group. The +PLM rates also showed a similar trend. However, +AM rates remained unchanged at approximately 10%, despite increasing risk (Fig.?1). The proportion of +AM within overall PSM http://www.selleckchem.com/products/CP-673451.html decreased gradually according to increasing risk. Rather, that of positive multifocal margins increased gradually according to increasing risk. Those of +BM and +PLM were similar regardless of the disease risk. http://www.selleckchem.com/products/rxdx-106-cep-40783.html On subgroup analyses according to the surgical procedure, a similar trend was observed (Fig.?1). In the univariate analysis considering preoperative parameters, PSA, prostate volume, clinical stage and biopsy GS were significantly associated with increased PSM risk after RP. In the multivariate analysis, high PSA, small prostate volume and high biopsy GS were independently associated with PSM. In the subgroup analysis according to the type of surgery, PSA, prostate volume ( https://en.wikipedia.org/wiki/Crotamiton +PLM and positive multifocal margin showed no statistically significant differences among the three types of surgery (Fig.?1). In the subgroup analysis according to the type of surgery, biopsy apical positive was the predictor of apical PSM in ORP and RALP. Small prostate volume was the predictor of +AM in ORP, but for +BM in RALP (Table?2). In survival analysis, all locations of PSM were independent predictors of biochemical recurrence (Fig.?2). The +BM and the positive multifocal margin showed worst prognoses on biochemical recurrence (HR 3.2, 95% CI 2.2�C4.6; HR 3.8, 95% CI 3.1�C4.6). Patients with +AM and +PLM had similar risks of disease progression (HR 1.9, 95% CI 1.5�C2.5; HR 1.9, 95% CI 1.4�C2.6). Precise preoperative prediction of surgical margin status and its location is of great clinical value for planning of surgical strategies and/or adjuvant treatments.