Neurotoxicity Associated with Cancer Treatment

Cancer is one of the prevalent medical problems among people especially in more developed and industrialized population. Now a day, it is considered as the third leading cause of death following cardiovascular problems and accidents. Moreover,the therapeutic approach to malignant tumors has been developed significantly compared with 70s and 80s. Many immunotherapies and targeted therapies have been developed and approved for both solid tumors and hematologic malignancies. Curable approach has been available for many deadly malignancies and multiple treatment lines have been proposed and validated based on the clinical trials in the majority of cancers. Innovative technologies such as nanotechnology have been proposed anddeveloped to optimize the bioavailability of the therapeutic agents within the tumor. However, adverse events associated with these novel therapeutic approaches have been inevitable. Many of these adverse events present acutely during or shortly after the completion of the chemotherapy and resolve spontaneously or with short term palliative approach or even reducing the dose and schedule of the chemotherapy protocol.

http://edelweisspublications.com/edelweiss/article/Neurotoxicity-Associated-Cancer-Treatment-ENOA-16-101.pdf