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We excluded other caregiver HRQOL scales for two reasons. First, on average, caregivers did not show poor HRQOL in these areas (they significantly exceeded normative levels, as noted earlier). Second, we had to limit the number of predictors included because we did not have a sufficient ratio of events to predictor variables to examine all possible predictors (60,61). Results indicated that the set of predictors contributed significantly to explaining time to mortality (improvement in fit over null model, ��2 (10) = 32.13, p https://www.selleck.cn/products/bgj398-nvp-bgj398.html status at 12 months posttransplant were both significant predictors of mortality: lung recipients were over twice as likely to die during the follow-up period as heart recipients, and for every 1 point decline in patients�� SF-36 physical functioning scores, patients�� risk of death was increased by 2% during the follow-up period. Beyond these effects, caregiver general health was also a significant, independent predictor of patients�� mortality risk. Thus, for every 1 point decline on the caregiver general health subscale, patients�� mortality risk increased https://www.selleckchem.com/products/Bortezomib.html by 2%. Analogously, for each 5-point decline on the caregiver general health subscale (the size of the change on the SF-36 scales that has been suggested to indicate a clinically important change; 62), patient mortality rates worsened by 10%. The impact of caregiver general health on patient mortality is shown graphically in Figure 2 in which we arbitrarily divided caregivers�� scores into 5 levels (scores of 0�C20, 21�C40, 41�C60, 61�C80 and 81�C100) for illustrative purposes (because we considered the measure as a continuous variable in the analyses). The poorer the caregivers�� general health score, the poorer the https://www.selleckchem.com/products/gsk1120212-jtp-74057.html patients�� survival time. Because 24 caregivers had withdrawn consent by 1-year posttransplant, these survival analyses are based only on caregivers remaining in the cohort. However, we examined whether patient survival time among these 24 caregivers differed from those who remained in the study and we found no differences in patient survival time between these groups. To our knowledge, ours is the first study to examine HRQOL in lung transplant recipients�� family caregivers over the first year posttransplant and to identify predictors of their HRQOL. In our sample, which included heart transplant caregivers as well, we found no differences by transplant type but instead observed that our total caregiver sample had HRQOL levels that remained high during the first year posttransplant across most domains, with two important exceptions. Caregivers�� physical functioning and bodily pain worsened over time and was no longer higher than normative levels by the end of the first year.