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Conclusion: The Grifols DG Gel? 8-column system is reliable and safe for routine tests performed in the immunohaematology laboratory. ""Eur J Clin Invest 2012; 42 (12): 1278�C1286 Background? In patients with carotid stenosis, we prospectively investigated the association of novel adipokines, apelin and visfatin, with gray-scale median (GSM) score, a valid index of carotid plaque vulnerability. We also assessed the impact of atorvastatin therapy on the above biochemical and imaging markers. Materials and methods? Seventy-four overweight [body-mass index (BMI)?>?25?kg/m2, fat-mass?>?30%], statin-free patients, with carotid stenosis, but without indications for intervention were enrolled. Thirty-eight age-, sex- and BMI-matched healthy subjects served as healthy controls (HC). All patients received gradual titrated (10�C80?mg) http://www.selleckchem.com/products/a-1331852.html atorvastatin therapy to target LDL-C? http://www.selleck.cn/products/PLX-4720.html 24?months. Results? At baseline, patients with carotid atherosclerosis had worse lipid profile, lower apelin and higher systolic BP, hsCRP, visfatin levels compared with HC (P? http://www.selleckchem.com/products/eai045.html (R2?=?0��411, P?=?0��011). Conclusion? Increased fat-mass, low apelin and high visfatin serum levels seem to correlate with carotid plaque vulnerability in patients with carotid stenosis. The atorvastatin-induced modification of apelin and LDL-C may beneficially affect carotid plaque stability. ""Eur J Clin Invest 2010; 40 (8): 742�C755 Background? Advanced glycation end-products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids. The kidney plays an important role in clearance and metabolism of AGEs. Methods? Medline? and other relevant databases were searched. In addition, key review articles were scanned for relevant original publication. Finally, original data from our research group were also included. Results? Kidney podocytes and endothelial cells express specific receptors for AGEs. Their activation leads to multiple pathophysiological effects including hypertrophy with cell cycle arrest and apoptosis, altered migration, and generation of proinflammatory cytokines.