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observed that the annualized decline in leg strength was: ?3.4% in white men, ?4.1% http://www.selleckchem.com/products/Imatinib-Mesylate.html in black men, ?2.6% in white women and ?3.0% in black women.[27] Hence, in our survey, despite that the ASM was relatively preserved, the decline in grip strength was particularly rapid (?5% per year) in Chinese women compared with the white and black older adults. In a systematic review of 41 publications involving 23?111 participants across the entire adult age range aged from 20 years old and older, Bohannon et?al. reported the gait speed at a normal pace was 1.33?m/s in men and 1.13 /s in women aged 70�C80 years.[31] These values are well above what we have observed, which were 1.07?m/s in men and 0.96?m/s in women. (Table?1) In our measurement of gait speed, we included both the acceleration and deceleration phase in the 6-m walk test, whereas the systematic review has only included studies that have made an allowance for the acceleration and deceleration factors. This can account for the wide difference between the present study and others. Previous studies showed that gait speed was relatively constant throughout adult life until after 65 years-of-age, when the decline started to accelerate. In general, it declined by 1�C2% per year, and rose up to 4% per year after the age of 80 years.[32-34] In our cohort, in men, the decline in gait speed started to decline fast after the second year follow up. (Fig.?3) The decline in the two older age groups, aged 75�C79 years http://www.selleck.cn/products/mi-773-sar405838.html and those above 80 years appeared more prominent. (Fig.?2). This age-cohort effect can also be illustrated by the more than twofold faster decline in gait speed per year in the older age group. (?0.038?s/m/year http://www.selleckchem.com/products/VX-770.html in >80 years group vs ?0.015?s/m/year in 65�C74 years group; P for trend