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1Columbia University, USA, 2New York Downtown Hospital, USA Chinese American (CH) women have lower hip and forearm fractures (fx) rates than Caucasian (CA) women despite lower areal http://www.selleck.cn/products/PD-98059.html bone density (aBMD) by dual x-ray absorptiometry (DXA). We recently reported higher trabecular (Dtrab) and cortical (Dcomp) bone density as well as greater trabecular (TbTh) and cortical thickness (CTh), but smaller bone area (CSA), as measured by high resolution peripheral QCT (HRpQCT) in premenopausal CH compared to CA women. The current study extends these investigations to postmenopausal women. The CH (n=29) & CA (n=30) groups did not differ in age (mean �� SD) (61 �� 2 vs. 62 �� 3 yrs; p=0.13) or in physical activity level. Height (62 �� http://www.selleckchem.com/products/Everolimus(RAD001).html 2 vs. 64 �� 2 inches; p http://www.selleckchem.com/products/Rapamycin.html vs. CA group (201 �� 33 vs. 227 �� 38 mm2, p=0.006). CTh (0.86 �� 0.14 vs. 0.75 �� 0.21 mm, p=0.03) and Dcomp was greater (916 �� 54 vs. 865 �� 86 mgHA/ccm; p=0.01) in CH compared to CA women but there was no difference in Dtrab (118 �� 36 vs. 132 �� 34 mgHA/ccm; p=0.13) or BV/TV (9.8 �� 3.0 vs. 11.0 �� 3.0%; p=0.13). Trabecular number (TbN) was lower (1.6 �� 0.3 vs.1.8 �� 0.3 1/mm, p=0.05) and separation (TbSp) was greater (0.597 �� 0.17 vs. 0.520 �� 0.11 mm, p=0.04) in CH compared to CA women. There was no difference in TbTh (0.061 �� 0.01 vs. 0.062 �� 0.01 mm, p=0.76). At the tibia results were similar though TbTh (0.078 �� 0.015 vs. 0.069 �� 0.012 mm, p =0.02) was also greater while Dtrab (138 �� 29 vs. 158 �� 25 mgHA/ccm, p=0.008) and BV/TV (0.115 �� 0.024 vs. 0.131 �� 0.021, p=0.008) were lower in CH compared to CA women. The results suggest that the racial differences in Dcomp and CTh persist after menopause and provide further evidence to support the idea that bone quality in CH women as determined by HRpQCT may help to account for their lower fracture risk in comparison to CA women.