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Clinical impact was scored as 'high�� if PET scanning changed the primary treatment modality or intent. The primary objective was to test the hypothesis that the true proportion of patients who have a ��high impact�� scan will be greater than 10%. Those patients that had post-therapy surveillance PET at least 1 month and no more than 6 months after completion of treatment were identified. Results: http://www.selleckchem.com/products/MK-1775.html 123 consecutive patients were included with 196 PET scans. Of these scans, 39 were performed as response assessment scans and 53 were performed for suspected relapse. The results of PET scanning had a high impact in 20% of patients (20/98) during staging (significantly higher than 10%, p?=?0.002), in 44% of patients (17/39) undergoing response assessment (p? http://www.selleck.cn/products/azd4547.html PET imaging had a high impact for staging, response assessment and ��re-staging�� at relapse. The presence of a CMR after potentially curative treatment was the strongest prognostic factor for survival. 083 �C Scientific Paper Does melanoma histology http://www.selleckchem.com/products/AZD6244.html predict for worse prognosis in patients with brain metastases treated with stereotactic radiosurgery? J Sia,1 E Paul,2 M Dally1,3 and J Ruben1,3 1William Buckland Radiotherapy Centre, Alfred Health, Melbourne, VIC, Australia, 2Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, VIC, Australia, 3Department of Surgery, Monash University, Melbourne, VIC, Australia Purpose: Melanoma brain metastases (BM) are consistently associated with worse survival compared to other histologies, but whether melanoma histology correlates with worse local control following stereotactic radiosurgery (SRS) is not yet well-defined. In this study we retrospectively reviewed patients with BM from various histologies treated with SRS and investigated the effects of host, tumour and treatment-related factors on survival and local control. Methods and Materials: Records of patients treated with SRS for BM between 2005 and 2011 were retrospectively reviewed.