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The performance of the proposed M1NCM-LUT method was evaluated through simulation and based on in vivo liver R2* relaxometry data. In both simulation and in vivo studies, the maximum absolute difference between R2* maps generated by the M1NCM and M1NCM-LUT methods was nearly 10?3 s?1 or less, and the M1NCM-LUT method obtained a R2* map in approximately 1 s and achieved an acceleration http://www.selleck.cn/products/Romidepsin-FK228.html of approximately five orders of magnitude. The proposed M1NCM-LUT method can significantly increase the speed of the liver R2* mapping using the M1NCM model. This development is important in promoting application of this R2* mapping technique for tissue iron quantification. Magn Reson Med, 2014. ? 2014 Wiley Periodicals, Inc. ""Intraplaque hemorrhage in atherosclerotic plaques has been associated with accelerated plaque growth as well as exacerbation of clinical symptoms. The identification of intraplaque hemorrhage using magnetic resonance imaging primarily relies on the detection of methemoglobin on T1 weighted images. Current techniques are limited by insufficient intraplaque hemorrhage-wall contrast and poor blood suppression. In this study, a slab-selective phase-sensitive inversion-recovery (SPI) technique is proposed by combining a phase-sensitive reconstruction with a T1 weighted sequence specifically designed to achieve improved intraplaque hemorrhage imaging. The SPI sequence was optimized and then used on ex vivo plaque specimens for histology based validation and intraplaque hemorrhage-wall contrast-to-noise ratio comparison with http://www.selleckchem.com/products/AC-220.html magnetization-prepared http://www.selleckchem.com/products/nutlin-3a.html 3D rapid acquisition gradient echo MP-RAGE. SPI and MP-RAGE were also tested on a group of atherosclerosis patients to compare in vivo intraplaque hemorrhage-wall contrast-to-noise ratio and blood suppression effectiveness. On ex vivo specimens SPI had better intraplaque hemorrhage identification accuracy and a significantly higher intraplaque hemorrhage-wall contrast-to-noise ratio (P = 0.01) than MP-RAGE. Similar results were found in the in vivo test: Slab-selective phase-sensitive inversion-recovery provided a significantly improved intraplaque hemorrhage-wall contrast-to-noise ratio (P