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The intent of comparison studies is to allow patients and physicians the ability to predict, preoperatively, from pretreatment parameters (e.g. stage, grade, PSA level, risk group) the prognostic possibilities with various treatments. The low-risk classification was uniform and consistent, with no deviation in the classic http://www.selleckchem.com/products/SB-431542.html definition of low-risk disease in all the studies (T1�CT2b, Gleason score ��?6, PSA level of http://www.selleck.cn/products/VX-770.html techniques. It is worth noting that by today's industry standard, 72?Gy is considered http://www.selleckchem.com/products/INCB18424.html as a low radiation dose. On the other hand, surgical technique, while technically superior in the recent years, has not to date, translated uniformly into improved clinical PSA-based results. The treatment periods reviewed generally involved treatments given within the past 15?years, as only papers published after 2000 were allowed, reflecting modern treatment and techniques. Caseload volume may influence any treatment result. However, a minimum number of patients were required for reporting purposes, eliminating small-volume centre reports. The commentators make a reasonable observation about the lack of studies conforming to standardised reporting. One limitation of this study was recognised, that very few robotic surgical articles to date report in a manner that allow for comparisons. One impact of this paper made be that more authors comply with, and more editors demand for, pretreatment stratification and PSA -based results, which would allow for more detailed comparisons to be performed. This is the first of many PCRSG comprehensive comparisons to come. Hopefully, more data will be available to allow for the subgroup analysis suggested.