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Results of PET scans interpreted as positive were confirmed by tissue biopsy or repeated imaging and clinical assessment performed within 6 months. A positive FU-PET scan was defined as true-positive (TP), and a negative scan was considered false-negative (FN) if relapse was confirmed within the first 6 months after imaging. A negative FU-PET study was defined as true-negative (TN) and a positive scan was defined as false-positive (FP) if no evidence of relapse was revealed for at least 6 months after evaluation. Clinical characteristics of relapse were analyzed in the whole http://www.selleckchem.com/products/MK-2206.html study group and compared between patients treated with CHOP or CHOP-R. Assessed parameters included: relapse frequency, remission duration, and incidence of asymptomatic relapse. Correlation of relapse frequency to demographic and pre-therapy risk factors, including gender, age, disease stage, and IPI were assessed and compared between the two patient groups. Statistical performance of FU-PET, defining sensitivity, specificity, accuracy, and predictive values for relapse detection was assessed for the whole cohort and separately for patients treated with CHOP versus CHOP-R. The relationship of FU-PET performance to various clinical parameters, including gender, age, stage of disease, and duration of CR till FU-PET were assessed. Analysis of involved sites included characterization of suspicious sites seen http://www.selleckchem.com/products/ABT-263.html on FU-PET in relation to their anatomic location in the study cohort as a whole and in two study groups. Data were analyzed using SPSS version 18. Descriptive statistics in terms of frequencies, standard normal distribution of quantitative variables was tested by the Kolmogorov�CSmirnov test. Mann Whitney U test was used to analyze differences in ��abnormally distributed�� variables. Fisher's exact test was used to determine relation between categorical variables. Logistic regression was employed to determine the variables predicting an FP result. P? http://www.selleck.cn/products/Erlotinib-Hydrochloride.html to detect a single truly positive scan was determined by dividing the entire number of surveillance PETs by the number of relapse events. A repeated analysis, assessing the number of scans required to capture a single event of asymptomatic relapse was calculated by dividing the entire number of surveillance PETs performed in the absence of symptoms, by the number of relapse events, captured at the same time. Data of 137 DLBCL patients, treated during the study period (1995�C2007), who achieved CR, were reviewed. Eighteen patients were excluded from further analysis, as no FU-PETs at remission were available for them.