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6 mmol/L); fasting total cholesterol >300 mg/dL (>7.8 mmol/L); fasting HDL-cholesterol 200 mg/dL; and any form of substance abuse, psychiatric disorder or condition that, in the opinion of the investigator, may invalidate communication with the investigator. Randomization codes:? Randomization codes were kept in sealed, individual http://www.selleckchem.com/products/Bortezomib.html envelopes and were opened sequentially immediately prior to transplant, ensuring that the next treatment assignment was not known by the surgeon until the time of transplant. Cytomegalovirus/pneumocystis http://www.selleckchem.com/products/gsk1120212-jtp-74057.html carinii pneumonia prophylaxis:? Prophylaxis for cytomegalovirus was with ganciclovir intravenously for 3 days, followed by daily valganciclovir orally for 3 months. In sero-positive donor to sero-negative recipients, treatment was for 6 months postoperatively. In patients treated with steroids or antilymphocyte therapy for an acute rejection episode, intravenous ganciclovir or valganciclovir was reinstituted. Single strength trimethoprim/sulfamethoxazole, 1 tablet orally (Monday, Wednesday, Friday) was given http://www.selleck.cn/products/bgj398-nvp-bgj398.html indefinitely for pneumocystis carinii pneumonia and nocardia prophylaxis. Statistical analysis:? Lastly, an analysis (using logrank tests) of first acute rejection rates based on actual treatment received was performed using a dichotomous time dependent covariate defined as whether the patient was receiving MMF (vs. Rapamycin) at follow-up time t (here, first acute rejections were compared according to which drug the patient was receiving immediately prior to the time of acute rejection, and any rejections and person-time of follow-up while patients were on neither drug were excluded from this analysis). Any withholding or discontinuation of rapamycin or mmf throughout the study period:? Overall, during the 10-year study 62% (53/86) and 42% (35/84) of patients had MMF and Rapamycin withheld or discontinued due to any reason in the two arms (p = 0.009). Reasons for withholding/discontinuance included GI symptoms (N = 27 in MMF vs. N = 2 in Rapamycin, p