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This review includes only the domains of the management of blood pressure, lipid control, glycemic control, and use of aspirin. Over the last 10?years, new randomized controlled trials (RCT) designed to study different blood pressure treatment targets did not find evidence that intensive systolic blood pressure control ( http://www.selleckchem.com/products/PF-2341066.html cardiovascular events in middle-aged and older adults, but data on niacin and fibrates is limited. Trials of statins and other lipid-lowering agents do not evaluate the cardiovascular effects on outcomes from treating lipids to different low-density lipoprotein cholesterol targets. No RCTs of lipid-lowering drugs enrolled significant numbers of adults aged 80 and older with or without DM. Three major RCTs that investigated intensive glycemic control did not find reductions in primary cardiovascular endpoints, and one study reported greater mortality with glycosylated hemoglobin of http://www.selleck.cn/products/3-methyladenine.html less than 6%. Two recently published RCTs were designed to study the cardiovascular benefits of aspirin use by individuals with DM. Neither trial found significantly fewer primary cardiovascular endpoints with aspirin than in control groups. Overall, RCTs enrolled few adults aged 80 and older or with significant comorbidities. More research is needed for clinicians to effectively customize care to older adults with DM because of heterogeneity in health status, comorbidities, duration of disease, frailty and functional status, and differences in life expectancy. New high-quality evidence from studies of the management and prevention of cardiovascular disease (CVD) in older adults with diabetes mellitus (DM) has been published in the last 10?years. During this same time, the treatment paradigm has shifted away from disease-focused http://www.selleckchem.com/products/r428.html treatment goals to patient-centered treatment recommendations. The evidence base for the prevention and management of CVD has grown for middle-aged adults but remains scant, at best, for individuals aged 80 and older. Although the majority of older adults are healthy, older adults with DM are a highly heterogeneous population, and research is generally not generalizable to those with poor functional status, complex comorbidities, and limited life expectancy. The updated clinical guideline recommendations that the American Geriatrics Society (AGS) has published provide guidance to clinicians who care for older adults with DM.[1] This report complements the recommendations and provides detail about important studies, with an emphasis on randomized controlled trials (RCTs) between 2002 and 2012.