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��2-tests were used to determine relationships between categorical variables. The Wilcoxon-rank test was used to determine associations between continuous variables and categories, and Spearman correlation coefficients were used to evaluate associations for continuous variables. All P values represented were two-sided and statistical significance was declared at P? http://www.selleckchem.com/products/loxo-101.html these patients is presented in Table?1. The median follow-up period for the cohort was 8��9?years (range: 0��3�C31?years) and for living patients (N?=?62) was 10��3?years (range: 0��6�C31?years). Twenty patients died of causes not related to lymphoma or the treatment of lymphoma, and 21 patients died secondary to relapse/progression of lymphoma. One patient was treated with single agent rituximab and one patient was treated with combined immunochemotherapy that included rituximab. Empirical ROC curves and AUC were used to determine the best cut-off points for AMC-DX and ALC/AMC-DX ratio, based on their utility as a marker for the clinical binary outcome of death/survival. AMC-DX ��0��6?��?109?cells/l had an AUC of 0��76 (95% CI, 0��70�C0��84%) with a sensitivity of 65% [95% confidence interval (CI), 55�C69%] and specificity of 77% (95% CI, 50�C92%) (Fig.?1A). ALC/AMC-DX ratio ��2��1 had an AUC of 0��82 (95% CI, 0��78�C0��90%) with a sensitivity http://www.selleckchem.com/products/abc294640.html of 70% (95% CI, 61�C76%) and a specificity of 84% (95% CI, 59�C92%) (Fig.?1C). An internal validation of AMC-DX and ALC/AMC-DX http://www.selleck.cn/products/ON-01910.html ratio performances as markers for the clinical binary outcome of death/survival was performed by the k-fold cross-validation with k?=?10. We obtained an average AUC?=?0��75 (95% CI, 0��67�C0��85%) over the 10 validation sets for AMC-DX, with a standard deviation of ��0��02. We also obtained an average AUC of 0��82 (95% CI, 0��72�C0��93%) over the 10 validation sets for ALC/AMC-DX ratio, with a standard deviation of ��0��02. We report the ROC curve for the complete data set used in the 10-fold procedure, by collecting the AMC-DX and ALC/AMC-DX ratio obtained on each fold. For AMC-DX, the cross-validation ROC curve (Fig.?1B) showed an AUC?=?0��75 (95% CI, 0��68�C0��86%), and for ALC/AMC-DX ratio an AUC?=?0��82 (95% CI, 0��71�C0��92%) (Fig.?1D). The similar areas under the curves from the empirical ROC curves and the cross-validation ROC curves support an AMC-DX ��0��6?��?109?cells/l and an ALC/AMC-DX ratio ��2��1 as the cut-off values for their use as markers of the binary clinical outcome of death/survival.