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Nineteen of the 20 dogs had negative serology for Babesia canis. The 1 dog that was serologically positive for Babesia canis, however, was negative for Babesia canis on PCR. Diagnostic imaging did not identify evidence of clinically relevant underlying disease in any dog. Bone marrow sampling was performed in 19 dogs at presentation to exclude megakaryocytic aplasia or other underlying bone marrow dysfunction. Bone marrow samples were not collected in 1 dog because the dog responded to treatment before sampling could be performed. Bone marrow aspirates were collected for cytological evaluation as the sole method of bone marrow sampling in 11 dogs, a bone marrow core biopsy was collected for histopathologic evaluation as the sole method of bone marrow sampling http://www.selleckchem.com/products/obeticholic-acid.html in 1 dog, and both aspirates and core samples were collected in 7 dogs. Findings included megakaryocytic hyperplasia (n?= 16), adequate numbers of megakaryocytes (n?=?1), and megakaryocytic hypoplasia (n?=?2). There were no identifiable immediate or delayed adverse drug reactions detected in any patients during hospitalization or follow-up. The median platelet recovery time for both groups was 2.5?days (P?=?.51) (Table?3). The median hospitalization time for all dogs that survived to discharge was 4?days. The median hospitalization was 5?days in the hIVIG group and http://www.selleckchem.com/products/Adriamycin.html 4?days in the VINC group, and was not different between groups (P?=?.29). Seven of 10 (70%) of the dogs in the hIVIG group survived to discharge and 10 of 10 (100%) of the VINC group survived to discharge. There was no statistical difference in survival to discharge between the 2 groups (P?=?.21). Hospitalization (days) (median and range) Platelet recovery http://www.selleck.cn/products/LY294002.html time (days) (median and range) Cost of treatment ($) (median and range) The mean cost of treatment was significantly higher in the hIVIG group ($4,108) than the VINC group ($2,426) (P?=?