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Lee22, K. T. Flaherty24, P. B. Chapman25 http://www.selleckchem.com/products/epz-6438.html 1 Universitaetsklinikum Schleswig-Holstein, Kiel Schleswig-Holstein, Germany; 2Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia; 3Cancer Institute Gustave Roussy, Villejuif, France; 4The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; 5Instituto Nazionale Tumori Pascale, Naples, Italy; 6Department of Medical Oncology, Royal Marsden Hospital, London, UK; 7Department of Dermatology, University of Zurich, Zurich, Switzerland; 8University of T��bingen, T��bingen, Germany; 9Istituto Europeo di Oncologia, Milan, Italy; 10Medical Oncology and Immunotherapy, University Hospital, Siena, Italy; 11Princess Margaret Hospital and University Health Network, Toronto, ON, Canada; http://www.selleck.cn/products/JNJ-26481585.html 12University of Manchester, Manchester, UK; 13Service de Dermatologie, H?pital Saint Louis, Paris, France; 14Sainte Andre Hospital, Bordeaux, France; 15University Hospital Essen, Essen, Germany; 16Department of Medicine, David Geffen School of Medicine at UCLA, CA, USA; 17Angeles Clinic and Research Institute, CA, USA; 18Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; 19Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA; 20Department of Dermatology, Nantes University Hospital, Nantes, France; 21Plexxikon Inc., Berkeley, CA, USA; 22Hoffman La Roche, Nutley, NJ, USA; 23Genentech, South San Francisco, CA, USA; 24Massachusetts General Hospital, Boston, MA, USA; 25Memorial Sloan-Kettering Cancer Center, New York, NY, USA Vemurafenib (Zelboraf?; http://www.selleckchem.com/products/PD-0325901.html PLX4032/RG7204/RO5185426) is an orally administered inhibitor of oncogenic BRAF kinase. The aim of the Phase III BRIM3 trial was to determine if vemurafenib improves overall survival (OS) in melanoma patients with the BRAFV600E mutation. Patients with previously untreated, unresectable stage IIIC or IV melanoma testing positive for the BRAFV600E mutation by the cobas? 4800 BRAF V600 Mutation Test (Roche Molecular Systems, Inc.) were randomized to vemurafenib (960?mg po bid) or dacarbazine (1000?mg/m2 IV q3w), stratified by performance status, stage, LDH, and region. At the planned OS interim analysis (50% of the 196 deaths needed for final analysis) the independent monitoring board recommended release of data because of a compelling OS hazard ratio (HR) of 0.37 (95% CI 0.26�C0.55; P?