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As can be seen in Fig.?1, the two CFS subgroups distinguished by postexercise adrenergic ��-2A increases versus decreases (described in detail below) did not differ from each other in ratings of pain or fatigue. Not surprisingly (because these patients were defined by having less pain than FM or CFS?+?FM patients), patients with CFS only had lower pain scores during and immediately after exercise than the CFS?+?FM or FM groups. Thus, this very moderate level of exercise for 25?min caused postexertional malaise lasting 48?h in all CFS and FM patient groups, but not controls. Patients http://www.selleckchem.com/products/gsk2126458.html with CFS compared with patients with CFS who also have comorbid FM.? Initially, we divided the patients with CFS into those that had CFS, but did not meet criteria for FM, and those patients with CFS who also met criteria for FM, i.e., they had both CFS and FM (CFS?+?FM). None of the descriptive variables in Table?1 were significantly different between these groups. Likewise, comparison of these two groups showed very similar gene expression both before and after exercise. Only postexercise ASIC3 AUC was greater in the CFS?+?FM versus the CFS-only patients (P? http://www.selleckchem.com/products/bay-57-1293.html from baseline levels. None of the CFS subgroups differed from controls in expression of any gene at baseline, either as separate subgroups or combined into a single CFS group (all P values >0.145). In contrast, the FM group showed several differences from controls at baseline before exercise. They had significantly higher baseline quantities of mRNA for sensory receptors P2X4 (P? http://www.selleck.cn/products/CAL-101.html These differences were unaltered after covarying for age and gender differences. Postexercise gene expression changes in patient subgroups versus controls.? Although their gene expression did not differ from controls prior to exercise, after exercise patients with CFS showed greater increases in mRNA than controls for seven of the genes under study. With all CFS subgroups combined, patients with CFS showed greater postexercise AUC increases than controls for P2X4, P2X5, TRPV1, ��-2A, ��-2, COMT and IL10 (P?