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The number of approaches to the capsule was recorded as an estimation of the number of sniffs, and an ANOVA was applied to analyze this behavior. The results indicate a main effect of the STRAIN (F1,16?=?19.606, P? https://www.selleckchem.com/products/SRT1720.html shows that the number of approaches to the stimulus capsule by C57BL/J6 mice is similar in the control and the TMT test day (9.2?��?1.9 vs. 7.1?��?1.6 times respectively; P?=?0.314) whereas CD1 mice show a pronounced, highly significant decrease in approaches to the TMT-containing capsule as compared to the https://en.wikipedia.org/wiki/MERTK control (21.8?��?1.9 vs. 13.3?��?1.6 times respectively; P?=?0.001). Even so, the number of approaches to the TMT by CD1 mice is higher than the approaches to the saline-containing capsule in the control test by C57BL7/J6 mice. In conclusion, having the possibility of not approaching the capsule when it contains TMT, mice do it. Although the number of approaches to the stimulus capsule displayed by CD1 mice is reduced by the presence of TMT, this can be interpreted as an aversion reflecting https://www.selleckchem.com/products/Adrucil(Fluorouracil).html disgust or displeasure rather than fear, as it is not paralleled by increased immobility. Our data suggest that TMT is aversive but not frightening. This contradicts previous data in the literature and can contribute to the debate on the kairomonal versus disgusting/irritating nature of TMT. The evidence supporting a kairomonal role of TMT include: a) it is present in fox feces (Vernet-Maury, 1980); b) it induces immobility (in a dose dependent way) and avoidance in rats (Endres et al., 2005; Rosen et al., 2006) and mice (e.g., Kobayakawa et al., 2007); c) it depresses foraging in lab conditions (lever-pressing for food; Endres et al., 2005); d) it potentiates the acoustic startle response (e.g., Endres et al., 2005); e) when more than 75 ��mol of TMT are presented to rats in a small cages, it increases corticosterone and adrenocroticotropin blood levels (Day et al., 2004), in a way apparently independent on the amount of TMT. However, there are problematic issues in the design of TMT experiments that deserve discussion. First, most authors use pure synthetic TMT, and vary the amount of stimulus presented to the animals from 1�C3 ��L to 0.1 mL. Because the molecular weight of TMT is 129.22 g mol?1 and the density of pure TMT is �� 1 g mL?1 (Bruce Thomson, Contech, personal communication) this makes a range of 7.74�C774 ��mol.