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We excluded the early ( subsequent multivariate analysis, http://www.selleckchem.com/products/crenolanib-cp-868596.html which used a logistic regression model with binary variables. The Kaplan�CMeier method with the log-rank test was used to calculate survival probabilities according to the initial site of recurrence and treatment method. The results are reported as hazard ratios (HR) with 95% confidence intervals. A p? in 52% (33/63) patients. After investigating the extent of the recurrences, curative resections were possible in only 6% (4/63) patients. The proportion of patients with multiple-organ recurrences increased from 52% (33/63) to 71% (45/63) during the follow-up period (mean follow-up duration after recurrence: 16.9?��?17.1?months; range: 1.1�C86.6?months). The median survival time after HCC recurrence was 12?months (range: 1.1�C86.6?months). Overall survival curve and the survival curve according to the initial recurrence sites are shown in Fig.?1. Fig.?1A,B shows the survival after transplantation and the survival after the diagnosis of recurrence, respectively. The one-, two-, and three-yr survival rates of patients with recurrences only in the lung were 90%, 75%, and 45%, respectively, while the survival rates for patients with recurrences only in the liver were 71%, 50%, and 36%, respectively. In patients with recurrences in multiple organs, the one-, two-, and three-yr survival rates were 33%, 4%, and 0%, respectively (Fig.?1B). The survival of patients with recurrences in multiple organs was significantly lower in comparison to those with recurrences in the lung only (p?