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The hospital mortality for all obstetric admissions (direct and indirect) in Set 1 was 2.8% (95% CI 2.2�C3.5%). Table?S3 (online only) shows the numbers of admissions with each specific ICNARC coding method obstetric condition and the mortality associated with each condition. http://www.selleck.cn/products/Erlotinib-Hydrochloride.html Peripartum or postpartum haemorrhage was the most common condition (47% of direct obstetric admissions), but with the lowest hospital mortality (0.8%). Table?1 shows the missing values associated with each variable. Values for the temperature variable were missing in http://www.selleckchem.com/products/MK-2206.html RR. The lowest systolic and diastolic BP are paired correlated values necessitating the inclusion of only one of the variables. The remaining significant variables (lowest total GCS, highest heart rate, lowest systolic BP, http://www.selleckchem.com/products/ABT-263.html minimum temperature, highest non-ventilated respiratory rate, hourly urine output and FIO2 associated with the lowest PaO2) were entered into a multiple logistic regression model. We then repeated the multiple logistic regression modelling substituting GCS first for ��AVPU�� and then for ��alert/not alert�� (Table?2). The regression equation coefficients were processed to factor in the size of change in the physiological variable. For example, SBP coefficient: 0.018 represents a 1?mmHg change in SBP therefore 0.36 (0.018?��?20) represents a 20?mmHg change (Table?2). The coefficients were then ��rounded�� and used to weight each covariate and create a statistically based obstetric EWS (Table?3). One of the significant variables was ��FIO2 associated with lowest PaO2 on arterial blood gas sampling��. From the data in Table?S4, it can be seen that the median lowest PaO2 values were similar for the non-survivors and survivors (11.45?kPa and 11.60?kPa, respectively), yet the median FIO2 value was noticeably higher for the non-survivors compared with the survivors (0.60 vs 0.30). The corresponding SpO2 value for a PaO2 equal to 11.5?kPa is 96% [13]. As ��FIO2 associated with lowest PaO2 on arterial blood gas sampling�� is not routinely measured in the ward environment, a surrogate variable of ��FIO2 to maintain SpO2?��?96%�� was identified (Table?3).