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Median time to reach ANC?>?0��5?��?109/l was 18?d (range 9�C50) in the growth factor group and 19 (10�C75) in the control group (P??0��5?��?109/l 1?month after HSCT was similar in the two groups: 89?��?1% (��SE) and 93?��?7%, respectively (ns). The probability of reaching platelet counts of >20?��?109/l 6?months after HSCT was 90?��?2% in patients receiving growth factors, which was significantly lower than in the controls (92?��?1%) (P?=?0��0002). The cumulative incidence of acute GVHD of grades II�CIV was 45?��?2% http://www.selleckchem.com/products/VX-770.html (SE) in the patients who were treated with growth factors and 39?��?1% in the controls (P?=?0��02). The cumulative incidence of chronic GVHD at 2?years was 38?��?3% and 31?��?1% in the respective groups (P?=?0��04). Of the patients treated with TBI, the cumulative incidence of acute http://www.selleckchem.com/products/ch5424802.html GVHD of grades II�CIV was 45?��?3% in the growth factor group and 40?��?2% in the controls (P?=?0��17). The cumulative incidence of chronic GVHD at 2?years was 39?��?3% and 30?��?2% in the two groups (P?=?0��007). Of the patients who were conditioned with chemotherapy only, acute GVHD of grades II�CIV occurred in 45?��?4% in the growth factor group and 35?��?2% in the control group (P?=?0��05). The cumulative incidence of chronic GVHD at 2?years was 33?��?6% in the growth factor group and 34?��?3% in the control group (P?=?0��68). Acute and chronic GVHD was significantly increased in the growth factor group in patients with AML in uni- and multivariate analysis, but not for patients with ALL (Table?2). At 10?years, the probability of GVHD-free survival in patients conditioned with TBI was 12?��?2% in those treated with growth factors, as opposed to 19?��?1% in the controls (Fig?1B) (P?=?0��001). In patients conditioned with chemotherapy only, the corresponding figures were 11?��?3% and 14?��?2% in the two groups (P?=?0��01) (Fig?1C). Among the centres who gave growth factor prophylaxis during a certain period, GVHD-free survival at 5?years was http://www.selleck.cn/products/Verteporfin(Visudyne).html 13?��?2% among those receiving growth factor, as opposed to 25?��?1% among the patients who did not receive growth factor (P?