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During a median follow-up time of 7.8 years [IQR 2.9, 13.5], 167 (2%) subjects developed ESKD, with an incidence rate of 2.2 cases per 1000 person-years. Pre-emptive kidney transplantation was performed in 49 (29%) subjects. Dialysis was initiated in the remaining 118 (71%) subjects; 58 of these subjects eventually received a kidney transplant, and 60 subjects remained on chronic dialysis until death http://www.selleckchem.com/products/blz945.html or last follow-up. The median time from LT to ESKD was 9.0 years [IQR 4.4, 13.4]. Figure 1 shows the cumulative incidence of ESKD, with death treated as a competing risk. During the same follow-up time, 2005 (22%) subjects died, with a mortality rate of 26.1 cases per 1000 person-years. The majority of deaths occurred early after LT, with a median time to death of only 0.6 years [IQR 0.1, 3.8]. Of the 2005 deaths in this cohort, 953 (48%) were reported by both the Social Security Death Master File and the transplant center, 984 (49%) were missed by the Death Master File but captured by the center, and only http://www.selleckchem.com/products/hydroxychloroquine-sulfate.html 68 (3%) were reported in the Death Master File but not by the center. Table 2 shows recipient risk factors associated with the development of ESKD in univariable and multivariable Cox regression. Older age at transplant compared to age http://www.selleck.cn/products/BafilomycinA1.html hepatitis C (HR 2.79, 95% CI 1.40�C5.58, p = 0.004), and eGFR pre-transplant