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0?��?109/l) in 70/204 (34.3%) lung transplant recipients and in 10/45 (22.2%) heart transplant recipients. The mean WCC of both groups http://www.selleckchem.com/products/z-vad-fmk.html was 9.8?��?5.8?��?109/l. Fourteen cases (5.6%) had eosinophilia (>0.04?��?109/l) at diagnosis, however, the overall mean eosinophil count was 0.15?��?0.01?��?109/l. C-reactive protein (normal range 0�C10?mg/l) was raised to >50?mg/l in 150/249 (60.2%) patients, moderately raised (10�C50) in 63/249 (25.3%) and normal ( http://www.selleck.cn/products/s-gsk1349572.html salvage therapy with amphotericin in one patient with a resistant Paecilomyces lilacinus infection was unsuccessful. The cost of drugs for a 6-week course of treatment at our centre is ?3672 for oral Voriconazole (200?mg BD), ?13,910 for intravenous Voriconazole (4?mg/kg bd) and ?14,880 for intravenous Caspofungin (50?mg od) compared with ?8862 or ?17,724 for AmBisome (Gilead, Great Abbingdon, UK) given at a dose of 1?mg/kg od or 3?mg/kg od respectively. Hepatotoxicity and nephrotoxicity were assessed by elevations in ALP, ALT, serum bilirubin and SCr during therapy [8]. The liver function tests showed an elevated ALP greater than three times the baseline value in 19 (7.6%) patients and greater than five times baseline values in 13 (5.2%) patients. Similarly ALT values of greater than three?times the baseline value were recorded in 20 (8.3%) patients and greater than five times baseline values in 15 (6%) patients. http://www.selleckchem.com/products/ly2157299.html Bilirubin rose by greater than one and a half times the baseline during therapy in 22 (8.8%) patients and three times the baseline in 14 (5.6%) patients. After successful therapy ALP returned to baseline in 24/32 patients, ALT in 27/35 patients and bilirubin in 28/36 patients on discharge from hospital. The SCr was raised one and a half times baseline value in 15 (6.0%) and twice the baseline value in a further 15 (6.0%) during therapy. Serum creatinine returned to baseline in 48/50 (96%) patients on hospital discharge. Raised liver function tests and serum creatinine were seen in all patient groups including those taking Voriconazole only, Caspofungin only and both Voriconazole and Caspofungin.