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The following data were registered: gender, age, reason for allo-SCT, presence of chronic GVHD (3, 6, 12 or 24?months after SCT), Karnofsky scores, presence of ocular GVHD, clinical manifestations of dry eye disease (visual acuity, Schirmer test, tear break-up time and corneal fluorescein staining) and duration of follow-up. In addition, the number of visits to an ophthalmologist and the treatment for ocular GVHD were assessed. http://www.selleckchem.com/products/MG132.html Ocular GVHD was diagnosed according to the criteria of Filipovich (2008), which includes two groups. The first group are patients with a maximal mean value of tear Schirmer test of both eyes of 5?mm at 5?min, and the second group includes all patients with a new onset of keratoconjunctivitis sicca documented by slit-lamp examination exhibiting mean values of 6�C10?mm on the Schirmer test if accompanied by distinctive manifestations of chronic GVHD in at least one other organ. We used the NIH scoring system (0�C3 points) to assess the severity of ocular GVHD (Filipovich 2008). The VFQ-25 (National Eye Institute (NEI) Dutch consensus translation version, van der Sterre et al. 2001) is a questionnaire that assesses the vision-related QoL and consists of 11 vision-specific domains and one question concerning general health. Each http://www.selleck.cn/products/Bleomycin-sulfate.html subscale is scored from 0 to 100, with 0 being the worst possible function and 100 being the best possible function. The 11 subscales are averaged to produce a VFQ total score ranging from 0 to 100, the general health subscale is not included in generating the composite score (Mangione et?al. 2001). The VFQ-25 was developed at the RAND Corporation under the sponsorship of the National Eye Institute. http://www.selleckchem.com/products/Rapamycin.html The OSDI (Dutch translation) is a 12-item validated questionnaire to assess OSD symptoms and its impact on vision-related QoL. The OSDI overall and subscale scores range from 0 to 100. The scoring of the OSDI and the VFQ-25 was performed according to the published guidelines (Miller et?al. 2010; Walt 2004). spss 15.0.1 (SPSS Inc., Chicago, IL, USA) was used for data analysis. The Kolmogorov�CSmirnov test was used as the test of normality. The t-test was used to calculate the p-value of normally distributed variables, and the Mann�CWhitney test and Kruskal�CWallis test were used to assess differences between questionnaire scores, clinical manifestations of dry eye disease and Karnofsky scores between patients with and without GVHD. The Pearson chi-square test or Fischer exact test was used for univariate analysis of categorical variables. Spearman��s rho was used to calculate ordinal variables. A p-value?