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The monoclonal antibody used has been shown to specifically bind to canine macrophages [31-33] and successfully applied in TAMs quantification in canine melanocytic lesions. [34] All the animals involved in this study had a surgical removal of the mammary tumours, without any other chemotherapeutic adjuvant treatment. Three months after the surgery, a consult was recommended to re-evaluate the animal. Other information was obtained consulting the registries of the clinical practices where these animals had been monitored. If the animals had multiple tumours, only one was selected in order to perform the immunohistochemical study http://www.selleckchem.com/products/pifithrin-alpha.html and the statistical associations with the follow-up variables. When more than one benign tumour was present, the largest size was selected. In those cases bearing more than one malignant tumour, the neoplasia with the more aggressive clinical and histologic features was selected, as previously described [35] and according to its histological grade of malignancy. [27] Overall survival was defined as the time (in months) from the date of surgery to the date of death caused by the tumour or the date of the last follow-up. After the date of surgery, the mean follow-up period was 19.5?months (range 2�C26). To compare TAMs infiltration between benign and malignant CMT, analysis of variance (ANOVA) was performed, using TAMs value as a continuous variable. Within malignant CMT, to determine whether TAMs' (MAC387+) infiltration differed by the clinical and pathological variables, a ��2 test was performed. The cut-off applied to split TAMs into two groups (low and high counting) was defined by the median value of TAMs in malignant CMT (low?��?55, high?>?55) since the sample studied does not follow a Gaussian distribution. The Kaplan�CMeier analysis was performed to determine whether TAMs high counting group was related to overall survival, the differences between high and low TAMs counting were studied by the log-rank test. All analyses were made using SPSS version 19.0 (Statistical Package for Social Sciences, IBM). P?